Enteric Polymer–Based Amorphous Solid Dispersions Enhance Oral Absorption of the Weakly Basic Drug Nintedanib via Stabilization of Supersaturation

The pH–induced crystallization of weakly basic drugs in the small intestine limits oral bioavailability. In this study, we investigated the solubilization and inhibitory effects on nintedanib in the presence of enteric polymers (HPMCAS LG, HPMCAS MG, Eudragit L100 55, and Eudragit L100). These polym...

Descripción completa

Detalles Bibliográficos
Autores principales: Qin, Yuling, Xiao, Chuyao, Li, Xiaoyue, Huang, Jiangeng, Si, Luqin, Sun, Minghui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9506478/
https://www.ncbi.nlm.nih.gov/pubmed/36145578
http://dx.doi.org/10.3390/pharmaceutics14091830

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9506478/
https://www.ncbi.nlm.nih.gov/pubmed/36145578
http://dx.doi.org/10.3390/pharmaceutics14091830

Ejemplares similares