Synthesis and Evaluation of Antiproliferative Activity, Topoisomerase IIα Inhibition, DNA Binding and Non-Clinical Toxicity of New Acridine–Thiosemicarbazone Derivatives

In this study, we report the synthesis of twenty new acridine–thiosemicarbazone derivatives and their antiproliferative activities. Mechanisms of action such as the inhibition of topoisomerase IIα and the interaction with DNA have been studied for some of the most active derivatives by means of both...

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Detalles Bibliográficos
Autores principales: Sousa, Gleyton, de Almeida, Maria C. F., Lócio, Lucas L., dos Santos, Vanda L., Bezerra, Daniel P., Silva, Valdenizia R., de Almeida, Sinara M. V., Simon, Alice, Honório, Thiago da S., Cabral, Lucio M., Castro, Rosane N., de Moura, Ricardo O., Kümmerle, Arthur E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9506480/
https://www.ncbi.nlm.nih.gov/pubmed/36145320
http://dx.doi.org/10.3390/ph15091098

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9506480/
https://www.ncbi.nlm.nih.gov/pubmed/36145320
http://dx.doi.org/10.3390/ph15091098

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