Synthesis and Structure–Activity Relationships for the Anti-Mycobacterial Activity of 3-Phenyl-N-(Pyridin-2-ylmethyl)Pyrazolo[1,5-a]Pyrimidin-7-Amines

Pyrazolo[1,5-a]pyrimidines have been reported as potent inhibitors of mycobacterial ATP synthase for the treatment of Mycobacterium tuberculosis (M.tb). In this work, we report the design and synthesis of approximately 70 novel 3,5-diphenyl-N-(pyridin-2-ylmethyl)pyrazolo[1,5-a]pyrimidin-7-amines and...

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Detalles Bibliográficos
Autores principales: Sutherland, Hamish S., Choi, Peter J., Lu, Guo-Liang, Giddens, Anna C., Tong, Amy S. T., Franzblau, Scott G., Cooper, Christopher B., Palmer, Brian D., Denny, William A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9506485/
https://www.ncbi.nlm.nih.gov/pubmed/36145345
http://dx.doi.org/10.3390/ph15091125

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9506485/
https://www.ncbi.nlm.nih.gov/pubmed/36145345
http://dx.doi.org/10.3390/ph15091125

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