Disulfiram Oxy-Derivatives Suppress Protein Retrotranslocation across the ER Membrane to the Cytosol and Initiate Paraptosis-like Cell Death

Disulfiram (DSF) and its derivatives were here investigated as antineoplastic agents, and their important feature is the ability to influence the UPS. We have recently shown that hydroxocobalamin catalyzes the aerobic oxidation of diethyldithiocarbamate to form disulfiram and its oxy-derivatives (DS...

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Detalles Bibliográficos
Autores principales: Solovieva, Marina, Shatalin, Yuri, Odinokova, Irina, Krestinina, Olga, Baburina, Yulia, Lomovskaya, Yana, Pankratov, Anton, Pankratova, Natalia, Buneeva, Olga, Kopylov, Arthur, Medvedev, Alexei, Akatov, Vladimir
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9506514/
https://www.ncbi.nlm.nih.gov/pubmed/36135864
http://dx.doi.org/10.3390/membranes12090845

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9506514/
https://www.ncbi.nlm.nih.gov/pubmed/36135864
http://dx.doi.org/10.3390/membranes12090845

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