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Functional architecture of pancreatic islets identifies a population of first responder cells that drive the first-phase calcium response

Insulin-secreting β-cells are functionally heterogeneous. Whether there exist cells driving the first-phase calcium response in individual islets, has not been examined. We examine “first responder” cells, defined by the earliest [Ca(2+)] response during first-phase [Ca(2+)] elevation, distinct from...

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Detalles Bibliográficos
Autores principales: Kravets, Vira, Dwulet, JaeAnn M., Schleicher, Wolfgang E., Hodson, David J., Davis, Anna M., Pyle, Laura, Piscopio, Robert A., Sticco-Ivins, Maura, Benninger, Richard K. P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9506623/
https://www.ncbi.nlm.nih.gov/pubmed/36099294
http://dx.doi.org/10.1371/journal.pbio.3001761