Design, synthesis, anti-proliferative evaluation, docking, and MD simulations studies of new thiazolidine-2,4-diones targeting VEGFR-2 and apoptosis pathway

We report herein, the design and synthesis of thiazolidine-2,4-diones derivatives as new inhibitors for VEGFR-2. The designed members were assessed for their in vitro anticancer activity against four cancer cell lines; A549, Caco-2, HepG-2 and MDA-MB-231. Compound 14a showed the most potent effects...

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Detalles Bibliográficos
Autores principales: Taghour, Mohammed S., Elkady, Hazem, Eldehna, Wagdy M., El-Deeb, Nehal, Kenawy, Ahmed M., Elkaeed, Eslam B., Alsfouk, Bshra A., Alesawy, Mohamed S., Husein, Dalal Z., Metwaly, Ahmed M., Eissa, Ibrahim H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9506633/
https://www.ncbi.nlm.nih.gov/pubmed/36149902
http://dx.doi.org/10.1371/journal.pone.0272362

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9506633/
https://www.ncbi.nlm.nih.gov/pubmed/36149902
http://dx.doi.org/10.1371/journal.pone.0272362

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