Role for N-glycans and calnexin-calreticulin chaperones in SARS-CoV-2 Spike maturation and viral infectivity

Functional and epidemiological data suggest that N-linked glycans on the SARS-CoV-2 Spike protein may contribute to viral infectivity. To investigate this, we created a panel of N-to-Q mutations at N-glycosylation sites proximal to the Spike S1-S2 (N61, N603, N657, and N616) and S2′ (N603 and N801)...

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Detalles Bibliográficos
Autores principales: Yang, Qi, Kelkar, Anju, Sriram, Anirudh, Hombu, Ryoma, Hughes, Thomas A., Neelamegham, Sriram
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2022
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9506717/
https://www.ncbi.nlm.nih.gov/pubmed/36149962
http://dx.doi.org/10.1126/sciadv.abq8678

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9506717/
https://www.ncbi.nlm.nih.gov/pubmed/36149962
http://dx.doi.org/10.1126/sciadv.abq8678

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