Structures of VWF tubules before and after concatemerization reveal a mechanism of disulfide bond exchange

von Willebrand factor (VWF) is an adhesive glycoprotein that circulates in the blood as disulfide-linked concatemers and functions in primary hemostasis. The loss of long VWF concatemers is associated with the excessive bleeding of type 2A von Willebrand disease (VWD). Formation of the disulfide bon...

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Detalles Bibliográficos
Autores principales: Anderson, Jacob R., Li, Jing, Springer, Timothy A., Brown, Alan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Hematology 2022
Materias:
Thrombosis and Hemostasis
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9507011/
https://www.ncbi.nlm.nih.gov/pubmed/35776905
http://dx.doi.org/10.1182/blood.2022016467

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9507011/
https://www.ncbi.nlm.nih.gov/pubmed/35776905
http://dx.doi.org/10.1182/blood.2022016467

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