ZO-2/Tjp2 suppresses Yap and Wwtr1/Taz-mediated hepatocyte to cholangiocyte transdifferentiation in the mouse liver

TJP2/ZO-2-inactivating mutations in humans cause progressive cholestatic liver disease. Liver-specific deletion of Tjp2 in the mouse (Tjp2 cKO mice) leads to mild progressive cholestasis without an overt degradation of the bile-blood barrier (BBB). These mice are more susceptible to cholic acid (CA)...

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Detalles Bibliográficos
Autores principales: Xu, Jianliang, Kausalya, P. Jaya, Ong, Alicia Ghia Min, Goh, Christine Meng Fan, Mohamed Ali, Safiah, Hunziker, Walter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9508083/
https://www.ncbi.nlm.nih.gov/pubmed/36151109
http://dx.doi.org/10.1038/s41536-022-00251-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9508083/
https://www.ncbi.nlm.nih.gov/pubmed/36151109
http://dx.doi.org/10.1038/s41536-022-00251-6

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