Treatment with a JAK1/2 inhibitor ameliorates murine autoimmune cholangitis induced by IFN overexpression

The interferon (IFN) signaling pathways are major immunological checkpoints with clinical significance in the pathogenesis of autoimmunity. We have generated a unique murine model named ARE-Del, with chronic overexpression of IFNγ, by altering IFNγ metabolism. Importantly, these mice develop an immu...

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Detalles Bibliográficos
Autores principales: Shao, Tihong, Leung, Patrick S. C., Zhang, Weici, Tsuneyama, Koichi, Ridgway, William M., Young, Howard A., Shuai, Zongwen, Ansari, Aftab A., Gershwin, M. Eric
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9508183/
https://www.ncbi.nlm.nih.gov/pubmed/36042351
http://dx.doi.org/10.1038/s41423-022-00904-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9508183/
https://www.ncbi.nlm.nih.gov/pubmed/36042351
http://dx.doi.org/10.1038/s41423-022-00904-y

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