Analysis of cellular kinetic models suggest that physiologically based model parameters may be inherently, practically unidentifiable

Physiologically-based pharmacokinetic and cellular kinetic models are used extensively to predict concentration profiles of drugs or adoptively transferred cells in patients and laboratory animals. Models are fit to data by the numerical optimisation of appropriate parameter values. When quantities...

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Detalles Bibliográficos
Autores principales: Brown, Liam V., Coles, Mark C., McConnell, Mark, Ratushny, Alexander V., Gaffney, Eamonn A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2022
Materias:
Original Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9508223/
https://www.ncbi.nlm.nih.gov/pubmed/35933452
http://dx.doi.org/10.1007/s10928-022-09819-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9508223/
https://www.ncbi.nlm.nih.gov/pubmed/35933452
http://dx.doi.org/10.1007/s10928-022-09819-7

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