Sphingosine kinase 1 promotes tumor immune evasion by regulating the MTA3-PD-L1 axis

Immune checkpoint blockade (ICB) exhibits considerable benefits in malignancies, but its overall response rate is limited. Previous studies have shown that sphingosine kinases (SPHKs) are critical in the tumor microenvironment (TME), but their role in immunotherapy is unclear. We performed integrati...

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Detalles Bibliográficos
Autores principales: Lau, Poyee, Zhang, Guanxiong, Zhao, Shuang, Liang, Long, Zhang, Hailun, Zhou, Guowei, Hung, Mien-Chie, Chen, Xiang, Liu, Hong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9508236/
https://www.ncbi.nlm.nih.gov/pubmed/36050478
http://dx.doi.org/10.1038/s41423-022-00911-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9508236/
https://www.ncbi.nlm.nih.gov/pubmed/36050478
http://dx.doi.org/10.1038/s41423-022-00911-z

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