Cargando…

Activation of the insulin receptor by an insulin mimetic peptide

Insulin receptor (IR) signaling defects cause a variety of metabolic diseases including diabetes. Moreover, inherited mutations of the IR cause severe insulin resistance, leading to early morbidity and mortality with limited therapeutic options. A previously reported selective IR agonist without seq...

Descripción completa

Detalles Bibliográficos
Autores principales:	Park, Junhee, Li, Jie, Mayer, John P., Ball, Kerri A., Wu, Jiayi, Hall, Catherine, Accili, Domenico, Stowell, Michael H. B., Bai, Xiao-chen, Choi, Eunhee
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9508239/ https://www.ncbi.nlm.nih.gov/pubmed/36151101 http://dx.doi.org/10.1038/s41467-022-33274-0

Ejemplares similares

Molecular basis for the role of disulfide-linked αCTs in the activation of insulin-like growth factor 1 receptor and insulin receptor
por: Li, Jie, et al.
Publicado: (2022)

Insulin receptor endocytosis in the pathophysiology of insulin resistance
por: Hall, Catherine, et al.
Publicado: (2020)

Structural basis of the activation of type 1 insulin-like growth factor receptor
por: Li, Jie, et al.
Publicado: (2019)

Reprogramming Cells to Make Insulin
por: McKimpson, Wendy M, et al.
Publicado: (2019)

Liver Sinusoidal Endothelial Cells Link Hyperinsulinemia to Hepatic Insulin Resistance
por: Tsuchiya, Kyoichiro, et al.
Publicado: (2013)

Insulin Action Research and the Future of Diabetes Treatment: The 2017 Banting Medal for Scientific Achievement Lecture
por: Accili, Domenico
Publicado: (2018)

Activation mechanism of the insulin receptor revealed by cryo-EM structure of the fully liganded receptor–ligand complex
por: Uchikawa, Emiko, et al.
Publicado: (2019)

An In Ovo Model for Testing Insulin-mimetic Compounds
por: Haselgrübler, Renate, et al.
Publicado: (2018)

Current Insights on the Use of Insulin and the Potential Use of Insulin Mimetics in Targeting Insulin Signalling in Alzheimer’s Disease
por: Woodfield, Amy, et al.
Publicado: (2022)

Activation of the human insulin receptor by non-insulin-related peptides
por: Kirk, Nicholas S., et al.
Publicado: (2022)

Gpr17 in AgRP Neurons Regulates Feeding and Sensitivity to Insulin and Leptin
por: Ren, Hongxia, et al.
Publicado: (2015)

Spindle Checkpoint Regulators in Insulin Signaling
por: Choi, Eunhee, et al.
Publicado: (2018)

Insulin Mimetic Properties of Extracts Prepared from Bellis perennis
por: Haselgrübler, Renate, et al.
Publicado: (2018)

Aldo-ketoreductase 1c19 ablation does not affect insulin secretion in murine islets
por: Miyachi, Yasutaka, et al.
Publicado: (2021)

Generation Of Functional Insulin-Producing Cells In The Gut By Foxo1 Ablation
por: Talchai, Chutima, et al.
Publicado: (2012)

Regulation of insulin-like growth factor–dependent myoblast differentiation by Foxo forkhead transcription factors
por: Hribal, Marta L., et al.
Publicado: (2003)

Glut4 expression defines an insulin-sensitive hypothalamic neuronal population
por: Ren, Hongxia, et al.
Publicado: (2014)

Pair Feeding, but Not Insulin, Phloridzin, or Rosiglitazone Treatment, Curtails Markers of β-Cell Dedifferentiation in db/db Mice
por: Ishida, Emi, et al.
Publicado: (2017)

Insulin Mimetic Peroxo Complexes of Vanadium Containing Uracil or Cytosine as Ligand
por: Sarkar, Asit R., et al.
Publicado: (2000)

Human Insulin Resistance Is Associated With Increased Plasma Levels of 12α-Hydroxylated Bile Acids
por: Haeusler, Rebecca A., et al.
Publicado: (2013)

Divergent Regulation of Energy Expenditure and Hepatic Glucose Production by Insulin Receptor in Agouti-Related Protein and POMC Neurons
por: Lin, Hua V., et al.
Publicado: (2010)

An alternatively spliced, non-signaling insulin receptor modulates insulin sensitivity via insulin peptide sequestration in C. elegans
por: Martinez, Bryan A, et al.
Publicado: (2020)

Ambulacrarian insulin-related peptides and their putative receptors suggest how insulin and similar peptides may have evolved from insulin-like growth factor
por: Veenstra, Jan A.
Publicado: (2021)

Insulin-mimetic compound hexaquis (benzylammonium) decavanadate is antilipolytic in human fat cells
por: Carpéné, Christian, et al.
Publicado: (2017)

Hydroxyoleoside-type seco-iridoids from Symplocos cochinchinensis and their insulin mimetic activity
por: Lee, Ba-Wool, et al.
Publicado: (2019)

Collagen Mimetic Peptides
por: Xu, Yujia, et al.
Publicado: (2021)

Expression of Concern. The IR(1152) Mutant Insulin Receptor Selectively Impairs Insulin Action in Skeletal Muscle but Not in Liver. Diabetes 2000;49:1194–1202. DOI: 10.2337/diabetes.49.7.1194. PMID: 10909978
por: Caruso, Matilde, et al.
Publicado: (2018)

Theoretical and Computational Studies of Peptides and Receptors of the Insulin Family
por: Vashisth, Harish
Publicado: (2015)

Homogeneous Insulin and C-Peptide Sensors for Rapid Assessment of Insulin and C-Peptide Secretion by the Islets
por: Heyduk, Ewa, et al.
Publicado: (2010)

Diabetes in Mice With Selective Impairment of Insulin Action in Glut4-Expressing Tissues
por: Lin, Hua V., et al.
Publicado: (2011)

Glucocorticoid Receptor β Overexpression Has Agonist-Independent Insulin-Mimetic Effects on HepG2 Glucose Metabolism
por: Sepúlveda-Quiñenao, Claudia, et al.
Publicado: (2022)

Effect of a GLP-1 mimetic on the insulin response to oral sugar testing in horses
por: Stefanovski, Darko, et al.
Publicado: (2022)

microRNA-205-5p is a modulator of insulin sensitivity that inhibits FOXO function
por: Langlet, Fanny, et al.
Publicado: (2018)

Disruption of Adipose Rab10-Dependent Insulin Signaling Causes Hepatic Insulin Resistance
por: Vazirani, Reema P., et al.
Publicado: (2016)

Insulin-Mimetic Action of Rhoifolin and Cosmosiin Isolated from Citrus grandis (L.) Osbeck Leaves: Enhanced Adiponectin Secretion and Insulin Receptor Phosphorylation in 3T3-L1 Cells
por: Rao, Yerra Koteswara, et al.
Publicado: (2011)

Inhibition of Notch signaling ameliorates insulin resistance in a FoxO1–dependent manner
por: Pajvani, Utpal B., et al.
Publicado: (2011)

Estradiol Binds to Insulin and Insulin Receptor Decreasing Insulin Binding in vitro
por: Root-Bernstein, Robert, et al.
Publicado: (2014)

Identification of novel insulin mimetic drugs by quantitative total internal reflection fluorescence (TIRF) microscopy
por: Lanzerstorfer, Peter, et al.
Publicado: (2014)

Insulin receptor trafficking steers insulin action
por: Hausmann, Simone, et al.
Publicado: (2016)

Insulin and Insulin Receptors in Adipose Tissue Development
por: Cignarelli, Angelo, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_96750ubohrnv451sqo3v58rvo7