Immune checkpoint expression on HIV-specific CD4+ T cells and response to their blockade are dependent on lineage and function

BACKGROUND: Immune checkpoint blockade (ICB) partially reverses the dysfunctional state of antigen-specific T cell in chronic infections. However, its impact on the diverse subsets of CD4+ T cells in humans is largely unknown. METHODS: We examined immune checkpoint (IC) expression and function in HI...

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Detalles Bibliográficos
Autores principales: Brunet-Ratnasingham, Elsa, Morou, Antigoni, Dubé, Mathieu, Niessl, Julia, Baxter, Amy E., Tastet, Olivier, Brassard, Nathalie, Ortega-Delgado, Gloria, Charlebois, Roxanne, Freeman, Gordon J., Tremblay, Cécile, Routy, Jean-Pierre, Kaufmann, Daniel E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9508408/
https://www.ncbi.nlm.nih.gov/pubmed/36150362
http://dx.doi.org/10.1016/j.ebiom.2022.104254

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9508408/
https://www.ncbi.nlm.nih.gov/pubmed/36150362
http://dx.doi.org/10.1016/j.ebiom.2022.104254

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