Two-component carnitine monooxygenase from Escherichia coli: functional characterization, inhibition and mutagenesis of the molecular interface

Gut microbial production of trimethylamine (TMA) from l-carnitine is directly linked to cardiovascular disease. TMA formation is facilitated by carnitine monooxygenase, which was proposed as a target for the development of new cardioprotective compounds. Therefore, the molecular understanding of the...

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Detalles Bibliográficos
Autores principales: Piskol, Fabian, Neubauer, Kerstin, Eggers, Maurice, Bode, Lisa Margarete, Jasper, Jan, Slusarenko, Alan, Reijerse, Edward, Lubitz, Wolfgang, Jahn, Dieter, Moser, Jürgen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Portland Press Ltd. 2022
Materias:
Enzymology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9508527/
https://www.ncbi.nlm.nih.gov/pubmed/36066069
http://dx.doi.org/10.1042/BSR20221102

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9508527/
https://www.ncbi.nlm.nih.gov/pubmed/36066069
http://dx.doi.org/10.1042/BSR20221102

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