NMR determination of the 2:1 binding complex of naphthyridine carbamate dimer (NCD) and CGG/CGG triad in double-stranded DNA

Trinucleotide repeat (TNR) diseases are caused by the aberrant expansion of CXG (X = C, A, G and T) sequences in genomes. We have reported two small molecules binding to TNR, NCD, and NA, which strongly bind to CGG repeat (responsible sequence of fragile X syndrome) and CAG repeat (Huntington's...

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Detalles Bibliográficos
Autores principales: Yamada, Takeshi, Furuita, Kyoko, Sakurabayashi, Shuhei, Nomura, Makoto, Kojima, Chojiro, Nakatani, Kazuhiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Chemical Biology and Nucleic Acid Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9508812/
https://www.ncbi.nlm.nih.gov/pubmed/36095126
http://dx.doi.org/10.1093/nar/gkac740

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9508812/
https://www.ncbi.nlm.nih.gov/pubmed/36095126
http://dx.doi.org/10.1093/nar/gkac740

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