Small-molecule activators specific to adenine base editors through blocking the canonical TGF-β pathway

Adenine base editors (ABEs) catalyze A-to-G conversions, offering therapeutic options to treat the major class of human pathogenic single nucleotide polymorphisms (SNPs). However, robust and precise editing at diverse genome loci remains challenging. Here, using high-throughput chemical screening, w...

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Detalles Bibliográficos
Autores principales: Yang, Yudong, Zhang, Chi, Song, Yixuan, Li, Yawen, Li, Pingping, Huang, Min, Meng, Feilong, Zhang, Mingliang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Chemical Biology and Nucleic Acid Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9508813/
https://www.ncbi.nlm.nih.gov/pubmed/36043443
http://dx.doi.org/10.1093/nar/gkac742

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9508813/
https://www.ncbi.nlm.nih.gov/pubmed/36043443
http://dx.doi.org/10.1093/nar/gkac742

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