Cargando…

Crystallographic analysis of engineered polymerases synthesizing phosphonomethylthreosyl nucleic acid

Xeno-nucleic acids (XNAs) are synthetic genetic polymers with backbone structures composed of non-ribose or non-deoxyribose sugars. Phosphonomethylthreosyl nucleic acid (pTNA), a type of XNA that does not base pair with DNA or RNA, has been suggested as a possible genetic material for storing synthe...

Descripción completa

Detalles Bibliográficos
Autores principales:	Hajjar, Mohammad, Chim, Nicholas, Liu, Chao, Herdewijn, Piet, Chaput, John C
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2022
Materias:	Chemical Biology and Nucleic Acid Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9508818/ https://www.ncbi.nlm.nih.gov/pubmed/36124684 http://dx.doi.org/10.1093/nar/gkac792

Ejemplares similares

CRISPR-Cas9 recognition of enzymatically synthesized base-modified nucleic acids
por: Yang, Hui, et al.
Publicado: (2023)

Stability and mechanism of threose nucleic acid toward acid-mediated degradation
por: Lee, Erica M, et al.
Publicado: (2023)

Kinetic analysis of N-alkylaryl carboxamide hexitol nucleotides as substrates for evolved polymerases
por: Renders, Marleen, et al.
Publicado: (2019)

Transliteration of synthetic genetic enzymes
por: Wang, Yajun, et al.
Publicado: (2021)

Crystal structures of a natural DNA polymerase that functions as an XNA reverse transcriptase
por: Jackson, Lynnette N, et al.
Publicado: (2019)

Synthesis and polymerase activity of a fluorescent cytidine TNA triphosphate analogue
por: Mei, Hui, et al.
Publicado: (2017)

Highly stable hexitol based XNA aptamers targeting the vascular endothelial growth factor
por: Eremeeva, Elena, et al.
Publicado: (2019)

Xylonucleic acid: synthesis, structure, and orthogonal pairing properties
por: Maiti, Mohitosh, et al.
Publicado: (2015)

Direct and site-specific quantification of RNA 2′-O-methylation by PCR with an engineered DNA polymerase
por: Aschenbrenner, Joos, et al.
Publicado: (2016)

Structural insight into DNA-assembled oligochromophores: crystallographic analysis of pyrene- and phenanthrene-modified DNA in complex with BpuJI endonuclease
por: Probst, Markus, et al.
Publicado: (2016)

Amino-acyl tXNA as inhibitors or amino acid donors in peptide synthesis
por: Rietmeyer, Lauriane, et al.
Publicado: (2022)

Characterization of an HNA aptamer suggests a non-canonical G-quadruplex motif
por: Schofield, Peter, et al.
Publicado: (2023)

Triggering nucleic acid nanostructure assembly by conditional kissing interactions
por: Azéma, Laurent, et al.
Publicado: (2018)

The NTP binding site of the polymerase ribozyme
por: Akoopie, Arvin, et al.
Publicado: (2018)

The phosphate clamp: sequence selective nucleic acid binding profiles and conformational induction of endonuclease inhibition by cationic Triplatin complexes
por: Prisecaru, Andreea, et al.
Publicado: (2014)

Recognition of single-stranded nucleic acids by small-molecule splicing modulators
por: Tang, Zhichao, et al.
Publicado: (2021)

Iron mediates catalysis of nucleic acid processing enzymes: support for Fe(II) as a cofactor before the great oxidation event
por: Okafor, C. Denise, et al.
Publicado: (2017)

Reactive OFF-ON type alkylating agents for higher-ordered structures of nucleic acids
por: Onizuka, Kazumitsu, et al.
Publicado: (2019)

Nucleoside analogs to manage sequence divergence in nucleic acid amplification and SNP detection
por: Yang, Zunyi, et al.
Publicado: (2018)

Chimeric siRNAs with chemically modified pentofuranose and hexopyranose nucleotides: altritol-nucleotide (ANA) containing GalNAc–siRNA conjugates: in vitro and in vivo RNAi activity and resistance to 5′-exonuclease
por: Kumar, Pawan, et al.
Publicado: (2020)

Polymerase-catalyzed synthesis of DNA from phosphoramidate conjugates of deoxynucleotides and amino acids
por: Adelfinskaya, O., et al.
Publicado: (2007)

Characterization of the interactions of chemically-modified therapeutic nucleic acids with plasma proteins using a fluorescence polarization assay
por: Gaus, Hans J, et al.
Publicado: (2019)

Molecular interactions underlying the phase separation of HP1α: role of phosphorylation, ligand and nucleic acid binding
por: Her, Cheenou, et al.
Publicado: (2022)

Cavity hairpin ThT-light nucleic acid switches: the construction of label- and enzyme-free sensing and imaging platforms
por: Lan, Xinyue, et al.
Publicado: (2023)

Influence of major-groove chemical modifications of DNA on transcription by bacterial RNA polymerases
por: Raindlová, Veronika, et al.
Publicado: (2016)

One-step enzymatic modification of RNA 3′ termini using polymerase θ
por: Thomas, Crystal, et al.
Publicado: (2019)

Polymerase synthesis of four-base DNA from two stable dimeric nucleotides
por: Mohsen, Michael G, et al.
Publicado: (2019)

Incorporating uracil and 5-halouracils into short peptide nucleic acids for enhanced recognition of A–U pairs in dsRNAs
por: Patil, Kiran M, et al.
Publicado: (2018)

DNA polymerase activity on synthetic N3′→P5′ phosphoramidate DNA templates
por: Lelyveld, Victor S, et al.
Publicado: (2019)

The use of an artificial nucleotide for polymerase-based recognition of carcinogenic O(6)-alkylguanine DNA adducts
por: Wyss, Laura A., et al.
Publicado: (2016)

Next-generation bis-locked nucleic acids with stacking linker and 2′-glycylamino-LNA show enhanced DNA invasion into supercoiled duplexes
por: Geny, Sylvain, et al.
Publicado: (2016)

Cationic porphyrins with large side arm substituents as resonance light scattering ratiometric probes for specific recognition of nucleic acid G-quadruplexes
por: Zhang, Li-Ming, et al.
Publicado: (2019)

The use of modified and non-natural nucleotides provide unique insights into pro-mutagenic replication catalyzed by polymerase eta
por: Choi, Jung-Suk, et al.
Publicado: (2016)

Mechanism of the extremely high duplex-forming ability of oligonucleotides modified with N-tert-butylguanidine- or N-tert-butyl-N′- methylguanidine-bridged nucleic acids
por: Yamaguchi, Takao, et al.
Publicado: (2023)

Structural interpretation of the effects of threo-nucleotides on nonenzymatic template-directed polymerization
por: Zhang, Wen, et al.
Publicado: (2020)

Improved genome editing by an engineered CRISPR-Cas12a
por: Ma, Enbo, et al.
Publicado: (2022)

Controlled sulfur-based engineering confers mouldability to phosphorothioate antisense oligonucleotides
por: Genna, Vito, et al.
Publicado: (2023)

siRNAs containing 2′-fluorinated Northern-methanocarbacyclic (2′-F-NMC) nucleotides: in vitro and in vivo RNAi activity and inability of mitochondrial polymerases to incorporate 2′-F-NMC NTPs
por: Akabane-Nakata, Masaaki, et al.
Publicado: (2021)

Extracellular vesicles engineered with valency-controlled DNA nanostructures deliver CRISPR/Cas9 system for gene therapy
por: Zhuang, Jialang, et al.
Publicado: (2020)

Engineering a responsive DNA triple helix into an octahedral DNA nanostructure for a reversible opening/closing switching mechanism: a computational and experimental integrated study
por: Ottaviani, Alessio, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_1i4ud5qgm3n7shcb1q2sj30dho