Tracking of progressing human DNA polymerase δ holoenzymes reveals distributions of DNA lesion bypass activities

During DNA replication, DNA lesions in lagging strand templates are initially encountered by DNA polymerase δ (pol δ) holoenzymes comprised of pol δ and the PCNA processivity sliding clamp. These encounters are thought to stall replication of an afflicted template before the lesion, activating DNA d...

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Detalles Bibliográficos
Autores principales: Dannenberg, Rachel L, Cardina, Joseph A, Pytko, Kara G, Hedglin, Mark
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Genome Integrity, Repair and Replication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9508823/
https://www.ncbi.nlm.nih.gov/pubmed/36107777
http://dx.doi.org/10.1093/nar/gkac745

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9508823/
https://www.ncbi.nlm.nih.gov/pubmed/36107777
http://dx.doi.org/10.1093/nar/gkac745

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