EWS/FLI mediated reprogramming of 3D chromatin promotes an altered transcriptional state in Ewing sarcoma

Ewing sarcoma is a prototypical fusion transcription factor-associated pediatric cancer that expresses EWS/FLI or a highly related FET/ETS chimera. EWS/FLI dysregulates transcription to induce and maintain sarcomagenesis, but the mechanisms utilized are not fully understood. We therefore sought to d...

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Detalles Bibliográficos
Autores principales: Showpnil, Iftekhar A, Selich-Anderson, Julia, Taslim, Cenny, Boone, Megann A, Crow, Jesse C, Theisen, Emily R, Lessnick, Stephen L
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Gene regulation, Chromatin and Epigenetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9508825/
https://www.ncbi.nlm.nih.gov/pubmed/36124657
http://dx.doi.org/10.1093/nar/gkac747

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9508825/
https://www.ncbi.nlm.nih.gov/pubmed/36124657
http://dx.doi.org/10.1093/nar/gkac747

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