Lamin A/C impairments cause mitochondrial dysfunction by attenuating PGC1α and the NAMPT-NAD(+) pathway

Mutations in the lamin A/C gene (LMNA) cause laminopathies such as the premature aging Hutchinson Gilford progeria syndrome (HGPS) and altered lamin A/C levels are found in diverse malignancies. The underlying lamin-associated mechanisms remain poorly understood. Here we report that lamin A/C-null m...

Descripción completa

Detalles Bibliográficos
Autores principales: Maynard, Scott, Hall, Arnaldur, Galanos, Panagiotis, Rizza, Salvatore, Yamamoto, Tatsuro, Gram, Helena Hagner, Munk, Sebastian H N, Shoaib, Muhammad, Sørensen, Claus Storgaard, Bohr, Vilhelm A, Lerdrup, Mads, Maya-Mendoza, Apolinar, Bartek, Jiri
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Molecular Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9508839/
https://www.ncbi.nlm.nih.gov/pubmed/36099415
http://dx.doi.org/10.1093/nar/gkac741

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9508839/
https://www.ncbi.nlm.nih.gov/pubmed/36099415
http://dx.doi.org/10.1093/nar/gkac741

Ejemplares similares