FGF receptor inhibitor BGJ398 partially rescues osteoarthritis-like phenotype in older high molecular weight FGF2 transgenic mice via multiple mechanisms

We have used Basic Fibroblast Growth Factor (FGF2) transgenic mice as experimental models for human X-linked hypophosphatemia (XLH)-related degenerative osteoarthritis (OA) to investigate the pathogenesis of the disease and to test potential pharmacotherapies for treatment. This study tested the eff...

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Detalles Bibliográficos
Autores principales: Hurley, Marja M., Coffin, J. Douglas, Doetschman, Thomas, Valera, Christina, Clarke, Kai, Xiao, Liping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9509331/
https://www.ncbi.nlm.nih.gov/pubmed/36153352
http://dx.doi.org/10.1038/s41598-022-20269-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9509331/
https://www.ncbi.nlm.nih.gov/pubmed/36153352
http://dx.doi.org/10.1038/s41598-022-20269-6

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