Inhibition of USP1 enhances anticancer drugs-induced cancer cell death through downregulation of survivin and miR-216a-5p-mediated upregulation of DR5

Ubiquitin-specific protease 1 (USP1) is a deubiquitinase involved in DNA damage repair by modulating the ubiquitination of major regulators, such as PCNA and FANCD2. Because USP1 is highly expressed in many cancers, dysregulation of USP1 contributes to cancer therapy. However, the role of USP1 and t...

Descripción completa

Detalles Bibliográficos
Autores principales: Woo, Seon Min, Kim, Seok, Seo, Seung Un, Kim, Shin, Park, Jong-Wook, Kim, Gyeonghwa, Choi, Yu-Ra, Hur, Keun, Kwon, Taeg Kyu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9509337/
https://www.ncbi.nlm.nih.gov/pubmed/36153316
http://dx.doi.org/10.1038/s41419-022-05271-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9509337/
https://www.ncbi.nlm.nih.gov/pubmed/36153316
http://dx.doi.org/10.1038/s41419-022-05271-0

Ejemplares similares