Comprehensive assessment of miniature CRISPR-Cas12f nucleases for gene disruption

Because of their small size, the recently developed CRISPR-Cas12f nucleases can be effectively packaged into adeno-associated viruses for gene therapy. However, a systematic evaluation of the editing outcomes of CRISPR-Cas12f is lacking. In this study, we apply a high-throughput sequencing method to...

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Detalles Bibliográficos
Autores principales: Xin, Changchang, Yin, Jianhang, Yuan, Shaopeng, Ou, Liqiong, Liu, Mengzhu, Zhang, Weiwei, Hu, Jiazhi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9509373/
https://www.ncbi.nlm.nih.gov/pubmed/36153319
http://dx.doi.org/10.1038/s41467-022-33346-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9509373/
https://www.ncbi.nlm.nih.gov/pubmed/36153319
http://dx.doi.org/10.1038/s41467-022-33346-1

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