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Comprehensive assessment of miniature CRISPR-Cas12f nucleases for gene disruption
Because of their small size, the recently developed CRISPR-Cas12f nucleases can be effectively packaged into adeno-associated viruses for gene therapy. However, a systematic evaluation of the editing outcomes of CRISPR-Cas12f is lacking. In this study, we apply a high-throughput sequencing method to...
Autores principales: | Xin, Changchang, Yin, Jianhang, Yuan, Shaopeng, Ou, Liqiong, Liu, Mengzhu, Zhang, Weiwei, Hu, Jiazhi |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9509373/ https://www.ncbi.nlm.nih.gov/pubmed/36153319 http://dx.doi.org/10.1038/s41467-022-33346-1 |
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