DNA methylation signatures of Alzheimer’s disease neuropathology in the cortex are primarily driven by variation in non-neuronal cell-types

Alzheimer’s disease (AD) is a chronic neurodegenerative disease characterized by the progressive accumulation of amyloid-beta and neurofibrillary tangles of tau in the neocortex. We profiled DNA methylation in two regions of the cortex from 631 donors, performing an epigenome-wide association study...

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Detalles Bibliográficos
Autores principales: Shireby, Gemma, Dempster, Emma L., Policicchio, Stefania, Smith, Rebecca G., Pishva, Ehsan, Chioza, Barry, Davies, Jonathan P., Burrage, Joe, Lunnon, Katie, Seiler Vellame, Dorothea, Love, Seth, Thomas, Alan, Brookes, Keeley, Morgan, Kevin, Francis, Paul, Hannon, Eilis, Mill, Jonathan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9509387/
https://www.ncbi.nlm.nih.gov/pubmed/36153390
http://dx.doi.org/10.1038/s41467-022-33394-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9509387/
https://www.ncbi.nlm.nih.gov/pubmed/36153390
http://dx.doi.org/10.1038/s41467-022-33394-7

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