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Molecular inhibition of RAS signalling to target ageing and age-related health

The RAS/MAPK pathway is a highly conserved signalling pathway with a well-established role in cancer. Mutations that hyperactivate this pathway are associated with unregulated cell proliferation. Evidence from a range of model organisms also links RAS/MAPK signalling to ageing. Genetic approaches th...

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Detalles Bibliográficos
Autores principales: Laskovs, Mihails, Partridge, Linda, Slack, Cathy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Ltd 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9510030/
https://www.ncbi.nlm.nih.gov/pubmed/36111627
http://dx.doi.org/10.1242/dmm.049627