Experimental method for haplotype phasing across the entire length of chromosome 21 in trisomy 21 cells using a chromosome elimination technique

Modern sequencing technologies produce a single consensus sequence without distinguishing between homologous chromosomes. Haplotype phasing solves this limitation by identifying alleles on the maternal and paternal chromosomes. This information is critical for understanding gene expression models in...

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Detalles Bibliográficos
Autores principales: Wakita, Sachiko, Hara, Mari, Kitabatake, Yasuji, Kawatani, Keiji, Kurahashi, Hiroki, Hashizume, Ryotaro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Nature Singapore 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9510051/
https://www.ncbi.nlm.nih.gov/pubmed/35637312
http://dx.doi.org/10.1038/s10038-022-01049-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9510051/
https://www.ncbi.nlm.nih.gov/pubmed/35637312
http://dx.doi.org/10.1038/s10038-022-01049-6

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