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Hydrophobicity is a key determinant in the activity of arginine-rich cell penetrating peptides

To deliver useful biological payloads into the cytosolic space of cells, cell-penetrating peptides have to cross biological membranes. The molecular features that control or enhance this activity remain unclear. Herein, a dimeric template of the arginine-rich HIV TAT CPP was used to establish the ef...

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Detalles Bibliográficos
Autores principales: Allen, Jason, Pellois, Jean-Philippe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9510126/
https://www.ncbi.nlm.nih.gov/pubmed/36156072
http://dx.doi.org/10.1038/s41598-022-20425-y