Effect of CRTH2 antagonism on the response to experimental rhinovirus infection in asthma: a pilot randomised controlled trial

BACKGROUND AND AIMS: The chemoattractant receptor-homologous molecule expressed on T helper type 2 cells (CRTH2) antagonist timapiprant improved lung function and asthma control in a phase 2 study, with evidence suggesting reduced exacerbations. We aimed to assess whether timapiprant attenuated or p...

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Detalles Bibliográficos
Autores principales: Farne, Hugo, Glanville, Nicholas, Johnson, Nicholas, Kebadze, Tata, Aniscenko, Julia, Regis, Eteri, Zhu, Jie, Trujillo-Torralbo, Maria-Belen, Kon, Onn Min, Mallia, Patrick, Prevost, A Toby, Edwards, Michael R, Johnston, Sebastian L, Singanayagam, Aran, Jackson, David J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2022
Materias:
Asthma
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9510426/
https://www.ncbi.nlm.nih.gov/pubmed/34716281
http://dx.doi.org/10.1136/thoraxjnl-2021-217429

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9510426/
https://www.ncbi.nlm.nih.gov/pubmed/34716281
http://dx.doi.org/10.1136/thoraxjnl-2021-217429

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