Prediction for optimal dosage of pazopanib under various clinical situations using physiologically based pharmacokinetic modeling

This study aimed to apply a physiologically based pharmacokinetic (PBPK) model to predict optimal dosing regimens of pazopanib (PAZ) for safe and effective administration when co-administered with CYP3A4 inhibitors, acid-reducing agents, food, and administered in patients with hepatic impairment. He...

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Detalles Bibliográficos
Autores principales: Wu, Chunnuan, Li, Bole, Meng, Shuai, Qie, Linghui, Zhang, Jie, Wang, Guopeng, Ren, Cong Cong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9510668/
https://www.ncbi.nlm.nih.gov/pubmed/36172188
http://dx.doi.org/10.3389/fphar.2022.963311

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9510668/
https://www.ncbi.nlm.nih.gov/pubmed/36172188
http://dx.doi.org/10.3389/fphar.2022.963311

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