Identification of a new member of Mortaparib class of inhibitors that target mortalin and PARP1

Mortalin, a heat shock family protein enriched in cancer cells, is known to inactivate tumor suppressor protein p53. Abrogation of mortalin-p53 interaction and reactivation of p53 has been shown to trigger growth arrest/apoptosis in cancer cells and hence, suggested to be useful in cancer therapy. I...

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Detalles Bibliográficos
Autores principales: Meidinna, Hazna Noor, Shefrin, Seyad, Sari, Anissa Nofita, Zhang, Huayue, Dhanjal, Jaspreet Kaur, Kaul, Sunil C., Sundar, Durai, Wadhwa, Renu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Cell and Developmental Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9510692/
https://www.ncbi.nlm.nih.gov/pubmed/36172283
http://dx.doi.org/10.3389/fcell.2022.918970

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9510692/
https://www.ncbi.nlm.nih.gov/pubmed/36172283
http://dx.doi.org/10.3389/fcell.2022.918970

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