Cargando…
Reliability and sensitivity analysis of double inverted-T nano-cavity label-free Si:HfO(2) ferroelectric junctionless TFET biosensors
In this work, we propose and simulate an ultrasensitive, label-free, and charge/dielectric modulated Si:HfO(2) ferroelectric junctionless tunnel field effect transistor (FE-JL-TFET) based biosensor. The proposed sensing device employs a dual inverted-T cavity and uses ferroelectric gate stacking of...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Royal Society of Chemistry
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9511230/ https://www.ncbi.nlm.nih.gov/pubmed/36276049 http://dx.doi.org/10.1039/d2ra03118c |
_version_ | 1784797617425743872 |
---|---|
author | Singh, Sangeeta Singh, Shradhya Mohammed, Mustafa K. A. Kishor Jha, Kamal Loan, Sajad A. |
author_facet | Singh, Sangeeta Singh, Shradhya Mohammed, Mustafa K. A. Kishor Jha, Kamal Loan, Sajad A. |
author_sort | Singh, Sangeeta |
collection | PubMed |
description | In this work, we propose and simulate an ultrasensitive, label-free, and charge/dielectric modulated Si:HfO(2) ferroelectric junctionless tunnel field effect transistor (FE-JL-TFET) based biosensor. The proposed sensing device employs a dual inverted-T cavity and uses ferroelectric gate stacking of Si-doped HfO(2), a key enabler of negative capacitance (NC) behavior. The two cavities are carved in gate-source underlap regions by a sacrificial etching technique to sense biomolecules such as streptavidin (2.1), bacteriophage T7 (6.3) and gelatin (12). Two dimensional (2D) calibrated simulations have been performed and the impact of various device parameters, including cavity length and height, on various performance measuring parameters has been studied. It has been observed that the biosensor exhibits better sensitivities for both neutral and charged biomolecules. The maximum values of the I(ON)/I(OFF) sensitivity for the neutral, positively charged and negatively charged biomolecules are as high as 3.77 × 10(9), 5.85 × 10(9), and 1.72 × 10(10), respectively. It has been observed that optimizing the cavity length and height can significantly improve the sensing capability of the proposed device. The comparative analysis of the proposed biosensor and other state of the art biosensors shows a significant improvement in the sensitivity (10(1) to 10(6) times) in the proposed biosensor. The detrimental effect of interface trapped charges on the biosensor performance is also analyzed in detail. |
format | Online Article Text |
id | pubmed-9511230 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | The Royal Society of Chemistry |
record_format | MEDLINE/PubMed |
spelling | pubmed-95112302022-10-21 Reliability and sensitivity analysis of double inverted-T nano-cavity label-free Si:HfO(2) ferroelectric junctionless TFET biosensors Singh, Sangeeta Singh, Shradhya Mohammed, Mustafa K. A. Kishor Jha, Kamal Loan, Sajad A. RSC Adv Chemistry In this work, we propose and simulate an ultrasensitive, label-free, and charge/dielectric modulated Si:HfO(2) ferroelectric junctionless tunnel field effect transistor (FE-JL-TFET) based biosensor. The proposed sensing device employs a dual inverted-T cavity and uses ferroelectric gate stacking of Si-doped HfO(2), a key enabler of negative capacitance (NC) behavior. The two cavities are carved in gate-source underlap regions by a sacrificial etching technique to sense biomolecules such as streptavidin (2.1), bacteriophage T7 (6.3) and gelatin (12). Two dimensional (2D) calibrated simulations have been performed and the impact of various device parameters, including cavity length and height, on various performance measuring parameters has been studied. It has been observed that the biosensor exhibits better sensitivities for both neutral and charged biomolecules. The maximum values of the I(ON)/I(OFF) sensitivity for the neutral, positively charged and negatively charged biomolecules are as high as 3.77 × 10(9), 5.85 × 10(9), and 1.72 × 10(10), respectively. It has been observed that optimizing the cavity length and height can significantly improve the sensing capability of the proposed device. The comparative analysis of the proposed biosensor and other state of the art biosensors shows a significant improvement in the sensitivity (10(1) to 10(6) times) in the proposed biosensor. The detrimental effect of interface trapped charges on the biosensor performance is also analyzed in detail. The Royal Society of Chemistry 2022-09-26 /pmc/articles/PMC9511230/ /pubmed/36276049 http://dx.doi.org/10.1039/d2ra03118c Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by/3.0/ |
spellingShingle | Chemistry Singh, Sangeeta Singh, Shradhya Mohammed, Mustafa K. A. Kishor Jha, Kamal Loan, Sajad A. Reliability and sensitivity analysis of double inverted-T nano-cavity label-free Si:HfO(2) ferroelectric junctionless TFET biosensors |
title | Reliability and sensitivity analysis of double inverted-T nano-cavity label-free Si:HfO(2) ferroelectric junctionless TFET biosensors |
title_full | Reliability and sensitivity analysis of double inverted-T nano-cavity label-free Si:HfO(2) ferroelectric junctionless TFET biosensors |
title_fullStr | Reliability and sensitivity analysis of double inverted-T nano-cavity label-free Si:HfO(2) ferroelectric junctionless TFET biosensors |
title_full_unstemmed | Reliability and sensitivity analysis of double inverted-T nano-cavity label-free Si:HfO(2) ferroelectric junctionless TFET biosensors |
title_short | Reliability and sensitivity analysis of double inverted-T nano-cavity label-free Si:HfO(2) ferroelectric junctionless TFET biosensors |
title_sort | reliability and sensitivity analysis of double inverted-t nano-cavity label-free si:hfo(2) ferroelectric junctionless tfet biosensors |
topic | Chemistry |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9511230/ https://www.ncbi.nlm.nih.gov/pubmed/36276049 http://dx.doi.org/10.1039/d2ra03118c |
work_keys_str_mv | AT singhsangeeta reliabilityandsensitivityanalysisofdoubleinvertedtnanocavitylabelfreesihfo2ferroelectricjunctionlesstfetbiosensors AT singhshradhya reliabilityandsensitivityanalysisofdoubleinvertedtnanocavitylabelfreesihfo2ferroelectricjunctionlesstfetbiosensors AT mohammedmustafaka reliabilityandsensitivityanalysisofdoubleinvertedtnanocavitylabelfreesihfo2ferroelectricjunctionlesstfetbiosensors AT kishorjhakamal reliabilityandsensitivityanalysisofdoubleinvertedtnanocavitylabelfreesihfo2ferroelectricjunctionlesstfetbiosensors AT loansajada reliabilityandsensitivityanalysisofdoubleinvertedtnanocavitylabelfreesihfo2ferroelectricjunctionlesstfetbiosensors |