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Reliability and sensitivity analysis of double inverted-T nano-cavity label-free Si:HfO(2) ferroelectric junctionless TFET biosensors

In this work, we propose and simulate an ultrasensitive, label-free, and charge/dielectric modulated Si:HfO(2) ferroelectric junctionless tunnel field effect transistor (FE-JL-TFET) based biosensor. The proposed sensing device employs a dual inverted-T cavity and uses ferroelectric gate stacking of...

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Autores principales: Singh, Sangeeta, Singh, Shradhya, Mohammed, Mustafa K. A., Kishor Jha, Kamal, Loan, Sajad A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9511230/
https://www.ncbi.nlm.nih.gov/pubmed/36276049
http://dx.doi.org/10.1039/d2ra03118c
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author Singh, Sangeeta
Singh, Shradhya
Mohammed, Mustafa K. A.
Kishor Jha, Kamal
Loan, Sajad A.
author_facet Singh, Sangeeta
Singh, Shradhya
Mohammed, Mustafa K. A.
Kishor Jha, Kamal
Loan, Sajad A.
author_sort Singh, Sangeeta
collection PubMed
description In this work, we propose and simulate an ultrasensitive, label-free, and charge/dielectric modulated Si:HfO(2) ferroelectric junctionless tunnel field effect transistor (FE-JL-TFET) based biosensor. The proposed sensing device employs a dual inverted-T cavity and uses ferroelectric gate stacking of Si-doped HfO(2), a key enabler of negative capacitance (NC) behavior. The two cavities are carved in gate-source underlap regions by a sacrificial etching technique to sense biomolecules such as streptavidin (2.1), bacteriophage T7 (6.3) and gelatin (12). Two dimensional (2D) calibrated simulations have been performed and the impact of various device parameters, including cavity length and height, on various performance measuring parameters has been studied. It has been observed that the biosensor exhibits better sensitivities for both neutral and charged biomolecules. The maximum values of the I(ON)/I(OFF) sensitivity for the neutral, positively charged and negatively charged biomolecules are as high as 3.77 × 10(9), 5.85 × 10(9), and 1.72 × 10(10), respectively. It has been observed that optimizing the cavity length and height can significantly improve the sensing capability of the proposed device. The comparative analysis of the proposed biosensor and other state of the art biosensors shows a significant improvement in the sensitivity (10(1) to 10(6) times) in the proposed biosensor. The detrimental effect of interface trapped charges on the biosensor performance is also analyzed in detail.
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spelling pubmed-95112302022-10-21 Reliability and sensitivity analysis of double inverted-T nano-cavity label-free Si:HfO(2) ferroelectric junctionless TFET biosensors Singh, Sangeeta Singh, Shradhya Mohammed, Mustafa K. A. Kishor Jha, Kamal Loan, Sajad A. RSC Adv Chemistry In this work, we propose and simulate an ultrasensitive, label-free, and charge/dielectric modulated Si:HfO(2) ferroelectric junctionless tunnel field effect transistor (FE-JL-TFET) based biosensor. The proposed sensing device employs a dual inverted-T cavity and uses ferroelectric gate stacking of Si-doped HfO(2), a key enabler of negative capacitance (NC) behavior. The two cavities are carved in gate-source underlap regions by a sacrificial etching technique to sense biomolecules such as streptavidin (2.1), bacteriophage T7 (6.3) and gelatin (12). Two dimensional (2D) calibrated simulations have been performed and the impact of various device parameters, including cavity length and height, on various performance measuring parameters has been studied. It has been observed that the biosensor exhibits better sensitivities for both neutral and charged biomolecules. The maximum values of the I(ON)/I(OFF) sensitivity for the neutral, positively charged and negatively charged biomolecules are as high as 3.77 × 10(9), 5.85 × 10(9), and 1.72 × 10(10), respectively. It has been observed that optimizing the cavity length and height can significantly improve the sensing capability of the proposed device. The comparative analysis of the proposed biosensor and other state of the art biosensors shows a significant improvement in the sensitivity (10(1) to 10(6) times) in the proposed biosensor. The detrimental effect of interface trapped charges on the biosensor performance is also analyzed in detail. The Royal Society of Chemistry 2022-09-26 /pmc/articles/PMC9511230/ /pubmed/36276049 http://dx.doi.org/10.1039/d2ra03118c Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by/3.0/
spellingShingle Chemistry
Singh, Sangeeta
Singh, Shradhya
Mohammed, Mustafa K. A.
Kishor Jha, Kamal
Loan, Sajad A.
Reliability and sensitivity analysis of double inverted-T nano-cavity label-free Si:HfO(2) ferroelectric junctionless TFET biosensors
title Reliability and sensitivity analysis of double inverted-T nano-cavity label-free Si:HfO(2) ferroelectric junctionless TFET biosensors
title_full Reliability and sensitivity analysis of double inverted-T nano-cavity label-free Si:HfO(2) ferroelectric junctionless TFET biosensors
title_fullStr Reliability and sensitivity analysis of double inverted-T nano-cavity label-free Si:HfO(2) ferroelectric junctionless TFET biosensors
title_full_unstemmed Reliability and sensitivity analysis of double inverted-T nano-cavity label-free Si:HfO(2) ferroelectric junctionless TFET biosensors
title_short Reliability and sensitivity analysis of double inverted-T nano-cavity label-free Si:HfO(2) ferroelectric junctionless TFET biosensors
title_sort reliability and sensitivity analysis of double inverted-t nano-cavity label-free si:hfo(2) ferroelectric junctionless tfet biosensors
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9511230/
https://www.ncbi.nlm.nih.gov/pubmed/36276049
http://dx.doi.org/10.1039/d2ra03118c
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