Balancing Affinity, Selectivity, and Cytotoxicity of Hydrazone-Based G-Quadruplex Ligands for Activation of Interferon β Genes in Cancer Cells

[Image: see text] G-quadruplex (G4) ligands are investigated to discover new anticancer drugs with increased cell-killing potency. These ligands can induce genome instability and activate innate immune genes at non-cytotoxic doses, opening the discovery of cytostatic immune-stimulating ligands. Howe...

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Detalles Bibliográficos
Autores principales: Marzano, Simona, Miglietta, Giulia, Morigi, Rita, Marinello, Jessica, Arleo, Andrea, Procacci, Monica, Locatelli, Alessandra, Leoni, Alberto, Pagano, Bruno, Randazzo, Antonio, Amato, Jussara, Capranico, Giovanni
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9511478/
https://www.ncbi.nlm.nih.gov/pubmed/36074772
http://dx.doi.org/10.1021/acs.jmedchem.2c00772

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9511478/
https://www.ncbi.nlm.nih.gov/pubmed/36074772
http://dx.doi.org/10.1021/acs.jmedchem.2c00772

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