Highly Potent and Selective Dopamine D(4) Receptor Antagonists Potentially Useful for the Treatment of Glioblastoma

[Image: see text] To better understand the role of dopamine D(4) receptor (D(4)R) in glioblastoma (GBM), in the present paper, new ligands endowed with high affinity and selectivity for D(4)R were discovered starting from the brain penetrant and D(4)R selective lead compound 1-(3-(4-phenylpiperazin-...

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Detalles Bibliográficos
Autores principales: Pavletić, Pegi, Semeano, Ana, Yano, Hideaki, Bonifazi, Alessandro, Giorgioni, Gianfabio, Piergentili, Alessandro, Quaglia, Wilma, Sabbieti, Maria Giovanna, Agas, Dimitrios, Santoni, Giorgio, Pallini, Roberto, Ricci-Vitiani, Lucia, Sabato, Emanuela, Vistoli, Giulio, Del Bello, Fabio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9511495/
https://www.ncbi.nlm.nih.gov/pubmed/36098685
http://dx.doi.org/10.1021/acs.jmedchem.2c00840

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9511495/
https://www.ncbi.nlm.nih.gov/pubmed/36098685
http://dx.doi.org/10.1021/acs.jmedchem.2c00840

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