Imatinib inhibits pericyte-fibroblast transition and inflammation and promotes axon regeneration by blocking the PDGF-BB/PDGFRβ pathway in spinal cord injury

BACKGROUND: Fibrotic scar formation and inflammation are characteristic pathologies of spinal cord injury (SCI) in the injured core, which has been widely regarded as the main barrier to axonal regeneration resulting in permanent functional recovery failure. Pericytes were shown to be the main sourc...

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Detalles Bibliográficos
Autores principales: Yao, Fei, Luo, Yang, Liu, Yan-Chang, Chen, Yi-Hao, Li, Yi-Teng, Hu, Xu-Yang, You, Xing-Yu, Yu, Shui-Sheng, Li, Zi-Yu, Chen, Lei, Tian, Da-Sheng, Zheng, Mei-Ge, Cheng, Li, Jing, Jue-Hua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9511779/
https://www.ncbi.nlm.nih.gov/pubmed/36163271
http://dx.doi.org/10.1186/s41232-022-00223-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9511779/
https://www.ncbi.nlm.nih.gov/pubmed/36163271
http://dx.doi.org/10.1186/s41232-022-00223-9

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