Single-cell multi-omics profiling links dynamic DNA methylation to cell fate decisions during mouse early organogenesis

BACKGROUND: Perturbation of DNA methyltransferases (DNMTs) and of the active DNA demethylation pathway via ten-eleven translocation (TET) methylcytosine dioxygenases results in severe developmental defects and embryonic lethality. Dynamic control of DNA methylation is therefore vital for embryogenes...

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Detalles Bibliográficos
Autores principales: Clark, Stephen J., Argelaguet, Ricard, Lohoff, Tim, Krueger, Felix, Drage, Deborah, Göttgens, Berthold, Marioni, John C., Nichols, Jennifer, Reik, Wolf
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9511790/
https://www.ncbi.nlm.nih.gov/pubmed/36163261
http://dx.doi.org/10.1186/s13059-022-02762-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9511790/
https://www.ncbi.nlm.nih.gov/pubmed/36163261
http://dx.doi.org/10.1186/s13059-022-02762-3

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