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Single-cell multi-omics profiling links dynamic DNA methylation to cell fate decisions during mouse early organogenesis

BACKGROUND: Perturbation of DNA methyltransferases (DNMTs) and of the active DNA demethylation pathway via ten-eleven translocation (TET) methylcytosine dioxygenases results in severe developmental defects and embryonic lethality. Dynamic control of DNA methylation is therefore vital for embryogenes...

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Detalles Bibliográficos
Autores principales:	Clark, Stephen J., Argelaguet, Ricard, Lohoff, Tim, Krueger, Felix, Drage, Deborah, Göttgens, Berthold, Marioni, John C., Nichols, Jennifer, Reik, Wolf
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2022
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9511790/ https://www.ncbi.nlm.nih.gov/pubmed/36163261 http://dx.doi.org/10.1186/s13059-022-02762-3

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