Autism risk gene POGZ promotes chromatin accessibility and expression of clustered synaptic genes

Deleterious genetic variants in POGZ, which encodes the chromatin regulator Pogo Transposable Element with ZNF Domain protein, are strongly associated with autism spectrum disorder (ASD). Although it is a high-confidence ASD risk gene, the neurodevelopmental functions of POGZ remain unclear. Here we...

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Detalles Bibliográficos
Autores principales: Markenscoff-Papadimitriou, Eirene, Binyameen, Fadya, Whalen, Sean, Price, James, Lim, Kenneth, Ypsilanti, Athena R., Catta-Preta, Rinaldo, Pai, Emily Ling-Lin, Mu, Xin, Xu, Duan, Pollard, Katherine S., Nord, Alex S., State, Matthew W., Rubenstein, John L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9512081/
https://www.ncbi.nlm.nih.gov/pubmed/34879283
http://dx.doi.org/10.1016/j.celrep.2021.110089

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9512081/
https://www.ncbi.nlm.nih.gov/pubmed/34879283
http://dx.doi.org/10.1016/j.celrep.2021.110089

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