Cargando…

Autism risk gene POGZ promotes chromatin accessibility and expression of clustered synaptic genes

Deleterious genetic variants in POGZ, which encodes the chromatin regulator Pogo Transposable Element with ZNF Domain protein, are strongly associated with autism spectrum disorder (ASD). Although it is a high-confidence ASD risk gene, the neurodevelopmental functions of POGZ remain unclear. Here we...

Descripción completa

Detalles Bibliográficos
Autores principales:	Markenscoff-Papadimitriou, Eirene, Binyameen, Fadya, Whalen, Sean, Price, James, Lim, Kenneth, Ypsilanti, Athena R., Catta-Preta, Rinaldo, Pai, Emily Ling-Lin, Mu, Xin, Xu, Duan, Pollard, Katherine S., Nord, Alex S., State, Matthew W., Rubenstein, John L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9512081/ https://www.ncbi.nlm.nih.gov/pubmed/34879283 http://dx.doi.org/10.1016/j.celrep.2021.110089

Ejemplares similares

Altered hippocampal-prefrontal communication during anxiety-related avoidance in mice deficient for the autism-associated gene Pogz
por: Cunniff, Margaret M, et al.
Publicado: (2020)

Common CHD8 Genomic Targets Contrast With Model-Specific Transcriptional Impacts of CHD8 Haploinsufficiency
por: Wade, A. Ayanna, et al.
Publicado: (2019)

Combinatorial transcription factor binding encodes cis-regulatory wiring of forebrain GABAergic neurogenesis
por: Catta-Preta, Rinaldo, et al.
Publicado: (2023)

De novo POGZ mutations in sporadic autism disrupt the DNA-binding activity of POGZ
por: Matsumura, Kensuke, et al.
Publicado: (2016)

Transcriptional network orchestrating regional patterning of cortical progenitors
por: Ypsilanti, Athéna R., et al.
Publicado: (2021)

Transcriptional Pathology Evolves over Time in Rat Hippocampus after Lateral Fluid Percussion Traumatic Brain Injury
por: Catta-Preta, Rinaldo, et al.
Publicado: (2021)

Single cell enhancer activity distinguishes GABAergic and cholinergic lineages in embryonic mouse basal ganglia
por: Su-Feher, Linda, et al.
Publicado: (2022)

POGZ truncating alleles cause syndromic intellectual disability
por: White, Janson, et al.
Publicado: (2016)

POGZ de novo missense variants in neuropsychiatric disorders
por: Zhao, Wenjing, et al.
Publicado: (2019)

De novo POGZ mutations are associated with neurodevelopmental disorders and microcephaly
por: Ye, Yizhou, et al.
Publicado: (2015)

A Novel POGZ Variant in a Patient with Intellectual Disability and Obesity
por: Giraldo-Ocampo, Sebastian, et al.
Publicado: (2022)

Synaptic, transcriptional, and chromatin genes disrupted in autism
por: De Rubeis, Silvia, et al.
Publicado: (2014)

Genotype-Phenotype Comparison in POGZ-Related Neurodevelopmental Disorders by Using Clinical Scoring
por: Nagy, Dóra, et al.
Publicado: (2022)

Genomic Resolution of DLX-Orchestrated Transcriptional Circuits Driving Development of Forebrain GABAergic Neurons
por: Lindtner, Susan, et al.
Publicado: (2019)

Pathogenic POGZ mutation causes impaired cortical development and reversible autism-like phenotypes
por: Matsumura, Kensuke, et al.
Publicado: (2020)

POGZ Is Required for Silencing Mouse Embryonic β-like Hemoglobin and Human Fetal Hemoglobin Expression
por: Gudmundsdottir, Bjorg, et al.
Publicado: (2018)

A case of White–Sutton syndrome arising from a maternally-inherited mutation in POGZ
por: Liu, Siqin, et al.
Publicado: (2021)

Autism-associated protein POGZ controls ESCs and ESC neural induction by association with esBAF
por: Sun, Xiaoyun, et al.
Publicado: (2022)

Pogz deficiency leads to transcription dysregulation and impaired cerebellar activity underlying autism-like behavior in mice
por: Suliman-Lavie, Reut, et al.
Publicado: (2020)

Identification of abnormally high expression of POGZ as a new biomarker associated with a poor prognosis in osteosarcoma
por: Zheng, Sikuan, et al.
Publicado: (2021)

Most chromatin interactions are not in linkage disequilibrium
por: Whalen, Sean, et al.
Publicado: (2019)

Author Correction: Pogz deficiency leads to transcription dysregulation and impaired cerebellar activity underlying autism-like behavior in mice
por: Suliman-Lavie, Reut, et al.
Publicado: (2021)

HOP1 and HAP2 are conserved components of the meiosis-related machinery required for successful mating in Leishmania
por: Catta-Preta, Carolina Moura Costa, et al.
Publicado: (2023)

Intranasal oxytocin administration ameliorates social behavioral deficits in a POGZ(WT/Q1038R) mouse model of autism spectrum disorder
por: Kitagawa, Kohei, et al.
Publicado: (2021)

Genetically Validated Drug Targets in Leishmania: Current Knowledge and Future Prospects
por: Jones, Nathaniel G., et al.
Publicado: (2018)

Widespread transcription at neuronal activity-regulated enhancers
por: Kim, Tae-Kyung, et al.
Publicado: (2010)

Genome sequence of Leishmania mexicana MNYC/BZ/62/M379 expressing Cas9 and T7 RNA polymerase
por: Beneke, Tom, et al.
Publicado: (2023)

MicroRNA Regulation of the Synaptic Plasticity-Related Gene Arc
por: Wibrand, Karin, et al.
Publicado: (2012)

A novel BRET-based assay to investigate binding and residence time of unmodified ligands to the human lysosomal ion channel TRPML1 in intact cells
por: Cunha, Micael R., et al.
Publicado: (2023)

Chromatin loops, gene positioning, and gene expression
por: Holwerda, Sjoerd, et al.
Publicado: (2012)

Pioneer Work with Cerebral Palsy
por: Collis, Eirene
Publicado: (1946)

Chromatin analysis of occluded genes
por: Lee, Jae Hyun, et al.
Publicado: (2009)

Chromosomal assembly of the nuclear genome of the endosymbiont-bearing trypanosomatid Angomonas deanei
por: Davey, John W, et al.
Publicado: (2020)

The autism-associated chromatin modifier CHD8 regulates other autism risk genes during human neurodevelopment
por: Cotney, Justin, et al.
Publicado: (2015)

Importance of Angomonas deanei KAP4 for kDNA arrangement, cell division and maintenance of the host-bacterium relationship
por: Gonçalves, Camila Silva, et al.
Publicado: (2021)

Chromatin, gene silencing and HIV latency
por: Mok, Hoi-Ping, et al.
Publicado: (2007)

Chromatin Structure Regulates Gene Conversion
por: Cummings, W. Jason, et al.
Publicado: (2007)

Cohesinopathies, gene expression, and chromatin organization
por: Bose, Tania, et al.
Publicado: (2010)

Transcription, chromatin condensation, and gene migration
por: McNally, James G.
Publicado: (2009)

Gene transcription and chromatin regulation in hypoxia
por: Batie, Michael, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_bol8v9mhdu9rnmifkt05ao23gh