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Keratinocyte PIEZO1 modulates cutaneous mechanosensation

Epidermal keratinocytes mediate touch sensation by detecting and encoding tactile information to sensory neurons. However, the specific mechanotransducers that enable keratinocytes to respond to mechanical stimulation are unknown. Here, we found that the mechanically-gated ion channel PIEZO1 is a ke...

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Detalles Bibliográficos
Autores principales: Mikesell, Alexander R, Isaeva, Olena, Moehring, Francie, Sadler, Katelyn E, Menzel, Anthony D, Stucky, Cheryl L
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9512397/
https://www.ncbi.nlm.nih.gov/pubmed/36053009
http://dx.doi.org/10.7554/eLife.65987