Keratinocyte PIEZO1 modulates cutaneous mechanosensation

Epidermal keratinocytes mediate touch sensation by detecting and encoding tactile information to sensory neurons. However, the specific mechanotransducers that enable keratinocytes to respond to mechanical stimulation are unknown. Here, we found that the mechanically-gated ion channel PIEZO1 is a ke...

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Detalles Bibliográficos
Autores principales: Mikesell, Alexander R, Isaeva, Olena, Moehring, Francie, Sadler, Katelyn E, Menzel, Anthony D, Stucky, Cheryl L
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2022
Materias:
Cell Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9512397/
https://www.ncbi.nlm.nih.gov/pubmed/36053009
http://dx.doi.org/10.7554/eLife.65987
Descripción
Sumario:Epidermal keratinocytes mediate touch sensation by detecting and encoding tactile information to sensory neurons. However, the specific mechanotransducers that enable keratinocytes to respond to mechanical stimulation are unknown. Here, we found that the mechanically-gated ion channel PIEZO1 is a key keratinocyte mechanotransducer. Keratinocyte expression of PIEZO1 is critical for normal sensory afferent firing and behavioral responses to mechanical stimuli in mice.

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