Keratinocyte PIEZO1 modulates cutaneous mechanosensation

Epidermal keratinocytes mediate touch sensation by detecting and encoding tactile information to sensory neurons. However, the specific mechanotransducers that enable keratinocytes to respond to mechanical stimulation are unknown. Here, we found that the mechanically-gated ion channel PIEZO1 is a ke...

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Detalles Bibliográficos
Autores principales: Mikesell, Alexander R, Isaeva, Olena, Moehring, Francie, Sadler, Katelyn E, Menzel, Anthony D, Stucky, Cheryl L
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2022
Materias:
Cell Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9512397/
https://www.ncbi.nlm.nih.gov/pubmed/36053009
http://dx.doi.org/10.7554/eLife.65987
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author Mikesell, Alexander R
Isaeva, Olena
Moehring, Francie
Sadler, Katelyn E
Menzel, Anthony D
Stucky, Cheryl L
author_facet Mikesell, Alexander R
Isaeva, Olena
Moehring, Francie
Sadler, Katelyn E
Menzel, Anthony D
Stucky, Cheryl L
author_sort Mikesell, Alexander R
collection PubMed
description Epidermal keratinocytes mediate touch sensation by detecting and encoding tactile information to sensory neurons. However, the specific mechanotransducers that enable keratinocytes to respond to mechanical stimulation are unknown. Here, we found that the mechanically-gated ion channel PIEZO1 is a key keratinocyte mechanotransducer. Keratinocyte expression of PIEZO1 is critical for normal sensory afferent firing and behavioral responses to mechanical stimuli in mice.
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spelling pubmed-95123972022-09-27 Keratinocyte PIEZO1 modulates cutaneous mechanosensation Mikesell, Alexander R Isaeva, Olena Moehring, Francie Sadler, Katelyn E Menzel, Anthony D Stucky, Cheryl L eLife Cell Biology Epidermal keratinocytes mediate touch sensation by detecting and encoding tactile information to sensory neurons. However, the specific mechanotransducers that enable keratinocytes to respond to mechanical stimulation are unknown. Here, we found that the mechanically-gated ion channel PIEZO1 is a key keratinocyte mechanotransducer. Keratinocyte expression of PIEZO1 is critical for normal sensory afferent firing and behavioral responses to mechanical stimuli in mice. eLife Sciences Publications, Ltd 2022-09-02 /pmc/articles/PMC9512397/ /pubmed/36053009 http://dx.doi.org/10.7554/eLife.65987 Text en © 2022, Mikesell et al https://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited.
spellingShingle Cell Biology
Mikesell, Alexander R
Isaeva, Olena
Moehring, Francie
Sadler, Katelyn E
Menzel, Anthony D
Stucky, Cheryl L
Keratinocyte PIEZO1 modulates cutaneous mechanosensation
title Keratinocyte PIEZO1 modulates cutaneous mechanosensation
title_full Keratinocyte PIEZO1 modulates cutaneous mechanosensation
title_fullStr Keratinocyte PIEZO1 modulates cutaneous mechanosensation
title_full_unstemmed Keratinocyte PIEZO1 modulates cutaneous mechanosensation
title_short Keratinocyte PIEZO1 modulates cutaneous mechanosensation
title_sort keratinocyte piezo1 modulates cutaneous mechanosensation
topic Cell Biology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9512397/
https://www.ncbi.nlm.nih.gov/pubmed/36053009
http://dx.doi.org/10.7554/eLife.65987
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AT sadlerkatelyne keratinocytepiezo1modulatescutaneousmechanosensation
AT menzelanthonyd keratinocytepiezo1modulatescutaneousmechanosensation
AT stuckycheryll keratinocytepiezo1modulatescutaneousmechanosensation

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