A genetically modified minipig model for Alzheimer’s disease with SORL1 haploinsufficiency

The established causal genes in Alzheimer’s disease (AD), APP, PSEN1, and PSEN2, are functionally characterized using biomarkers, capturing an in vivo profile reflecting the disease’s initial preclinical phase. Mutations in SORL1, encoding the endosome recycling receptor SORLA, are found in 2%–3% of...

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Detalles Bibliográficos
Autores principales: Andersen, Olav M., Bøgh, Nikolaj, Landau, Anne M., Pløen, Gro G., Jensen, Anne Mette G., Monti, Giulia, Ulhøi, Benedicte P., Nyengaard, Jens R., Jacobsen, Kirsten R., Jørgensen, Margarita M., Holm, Ida E., Kristensen, Marianne L., Alstrup, Aage Kristian O., Hansen, Esben S.S., Teunissen, Charlotte E., Breidenbach, Laura, Droescher, Mathias, Liu, Ying, Pedersen, Hanne S., Callesen, Henrik, Luo, Yonglun, Bolund, Lars, Brooks, David J., Laustsen, Christoffer, Small, Scott A., Mikkelsen, Lars F., Sørensen, Charlotte B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9512670/
https://www.ncbi.nlm.nih.gov/pubmed/36099918
http://dx.doi.org/10.1016/j.xcrm.2022.100740

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9512670/
https://www.ncbi.nlm.nih.gov/pubmed/36099918
http://dx.doi.org/10.1016/j.xcrm.2022.100740

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