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Modeling receptor flexibility in the structure-based design of KRAS(G12C) inhibitors
KRAS has long been referred to as an ‘undruggable’ target due to its high affinity for its cognate ligands (GDP and GTP) and its lack of readily exploited allosteric binding pockets. Recent progress in the development of covalent inhibitors of KRAS(G12C) has revealed that occupancy of an allosteric...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Springer International Publishing
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9512760/ https://www.ncbi.nlm.nih.gov/pubmed/35930206 http://dx.doi.org/10.1007/s10822-022-00467-0 |