β-arrestin1 and 2 exhibit distinct phosphorylation-dependent conformations when coupling to the same GPCR in living cells

β-arrestins mediate regulatory processes for over 800 different G protein-coupled receptors (GPCRs) by adopting specific conformations that result from the geometry of the GPCR–β-arrestin complex. However, whether β-arrestin1 and 2 respond differently for binding to the same GPCR is still unknown. E...

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Detalles Bibliográficos
Autores principales: Haider, Raphael S., Matthees, Edda S. F., Drube, Julia, Reichel, Mona, Zabel, Ulrike, Inoue, Asuka, Chevigné, Andy, Krasel, Cornelius, Deupi, Xavier, Hoffmann, Carsten
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9512828/
https://www.ncbi.nlm.nih.gov/pubmed/36163356
http://dx.doi.org/10.1038/s41467-022-33307-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9512828/
https://www.ncbi.nlm.nih.gov/pubmed/36163356
http://dx.doi.org/10.1038/s41467-022-33307-8

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