USP14 promotes tryptophan metabolism and immune suppression by stabilizing IDO1 in colorectal cancer

Indoleamine 2,3 dioxygenase 1 (IDO1) is an attractive target for cancer immunotherapy. However, IDO1 inhibitors have shown disappointing therapeutic efficacy in clinical trials, mainly because of the activation of the aryl hydrocarbon receptor (AhR). Here, we show a post-transcriptional regulatory m...

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Detalles Bibliográficos
Autores principales: Shi, Dongni, Wu, Xianqiu, Jian, Yunting, Wang, Junye, Huang, Chengmei, Mo, Shuang, Li, Yue, Li, Fengtian, Zhang, Chao, Zhang, Dongsheng, Zhang, Huizhong, Huang, Huilin, Chen, Xin, Wang, Y. Alan, Lin, Chuyong, Liu, Guozhen, Song, Libing, Liao, Wenting
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9513055/
https://www.ncbi.nlm.nih.gov/pubmed/36163134
http://dx.doi.org/10.1038/s41467-022-33285-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9513055/
https://www.ncbi.nlm.nih.gov/pubmed/36163134
http://dx.doi.org/10.1038/s41467-022-33285-x

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