P14AS upregulates gene expression in the CDKN2A/2B locus through competitive binding to PcG protein CBX7

Background: It is well known that P16 ( INK4A ), P14 ( ARF ), P15 ( INK4B ) mRNAs, and ANRIL lncRNA are transcribed from the CDKN2A/2B locus. LncRNA P14AS is a lncRNA transcribed from antisense strand of P14 ( ARF ) promoter to intron-1. Our previous study showed that P14AS could upregulate the expr...

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Detalles Bibliográficos
Autores principales: Li, Zhuoqi, Qiao, Juanli, Ma, Wanru, Zhou, Jing, Gu, Liankun, Deng, Dajun, Zhang, Baozhen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Cell and Developmental Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9513069/
https://www.ncbi.nlm.nih.gov/pubmed/36176277
http://dx.doi.org/10.3389/fcell.2022.993525

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9513069/
https://www.ncbi.nlm.nih.gov/pubmed/36176277
http://dx.doi.org/10.3389/fcell.2022.993525

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