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P14AS upregulates gene expression in the CDKN2A/2B locus through competitive binding to PcG protein CBX7
Background: It is well known that P16 ( INK4A ), P14 ( ARF ), P15 ( INK4B ) mRNAs, and ANRIL lncRNA are transcribed from the CDKN2A/2B locus. LncRNA P14AS is a lncRNA transcribed from antisense strand of P14 ( ARF ) promoter to intron-1. Our previous study showed that P14AS could upregulate the expr...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Frontiers Media S.A.
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9513069/ https://www.ncbi.nlm.nih.gov/pubmed/36176277 http://dx.doi.org/10.3389/fcell.2022.993525 |