Cargando…

Elevated SFXN2 limits mitochondrial autophagy and increases iron-mediated energy production to promote multiple myeloma cell proliferation

Human sideroflexin 2 (SFXN2) belongs to the SFXN protein family, which is a mitochondrial outer membrane protein involved in mitochondrial iron metabolism. Mitochondria are indispensable for cellular energy production and iron metabolism. However, it remains elusive how SFXN2 modulates mitochondrial...

Descripción completa

Detalles Bibliográficos
Autores principales:	Chen, Ying, Qian, Jinjun, Ding, Pinggang, Wang, Wang, Li, Xinying, Tang, Xiaozhu, Tang, Chao, Yang, Ye, Gu, Chunyan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9513108/ https://www.ncbi.nlm.nih.gov/pubmed/36163342 http://dx.doi.org/10.1038/s41419-022-05272-z

Ejemplares similares

The mitochondrial carrier SFXN1 is critical for complex III integrity and cellular metabolism
por: Acoba, Michelle Grace, et al.
Publicado: (2021)

The mitochondrial protein Sideroflexin 3 (SFXN3) influences neurodegeneration pathways in vivo
por: Ledahawsky, Leire M., et al.
Publicado: (2022)

Comprehensive analysis of the role of SFXN family in breast cancer
por: Yuan, Ding, et al.
Publicado: (2023)

AHSA1 is a promising therapeutic target for cellular proliferation and proteasome inhibitor resistance in multiple myeloma
por: Gu, Chunyan, et al.
Publicado: (2022)

Correction: AHSA1 is a promising therapeutic target for cellular proliferation and proteasome inhibitor resistance in multiple myeloma
por: Gu, Chunyan, et al.
Publicado: (2023)

CD229 interacts with RASAL3 to activate RAS/ERK pathway in multiple myeloma proliferation
por: Lin, Zigen, et al.
Publicado: (2022)

Correction for: CD229 interacts with RASAL3 to activate RAS/ERK pathway in multiple myeloma proliferation
por: Lin, Zigen, et al.
Publicado: (2023)

A novel protein encoded by circHNRNPU promotes multiple myeloma progression by regulating the bone marrow microenvironment and alternative splicing
por: Tang, Xiaozhu, et al.
Publicado: (2022)

BUB1B and circBUB1B_544aa aggravate multiple myeloma malignancy through evoking chromosomal instability
por: Tang, Xiaozhu, et al.
Publicado: (2021)

Targeting RFWD2 as an Effective Strategy to Inhibit Cellular Proliferation and Overcome Drug Resistance to Proteasome Inhibitor in Multiple Myeloma
por: Guo, Mengjie, et al.
Publicado: (2021)

Loss of SFXN1 mitigates lipotoxicity and predicts poor outcome in non-viral hepatocellular carcinoma
por: Yagi, Kohei, et al.
Publicado: (2023)

DAZAP1 facilitates the alternative splicing of KITLG to promote multiple myeloma cell proliferation via ERK signaling pathway
por: Zhou, Yanyan, et al.
Publicado: (2022)

SFXN3 is Associated with Poor Clinical Outcomes and Sensitivity to the Hypomethylating Therapy in Non-M3 Acute Myeloid Leukemia Patients
por: Dong, Yuxuan, et al.
Publicado: (2023)

Review on circular RNAs and new insights into their roles in cancer
por: Tang, Xiaozhu, et al.
Publicado: (2021)

A High-Throughput Search for SFXN1 Physical Partners Led to the Identification of ATAD3, HSD10 and TIM50
por: Tifoun, Nesrine, et al.
Publicado: (2022)

Acupuncture Synergized With Bortezomib Improves Survival of Multiple Myeloma Mice via Decreasing Metabolic Ornithine
por: Ke, Mengying, et al.
Publicado: (2021)

Splicing factor arginine/serine‐rich 8 promotes multiple myeloma malignancy and bone lesion through alternative splicing of CACYBP and exosome‐based cellular communication
por: Zhang, Yuanjiao, et al.
Publicado: (2022)

Non-coding RNA-mediated high expression of SFXN3 as a prognostic biomarker associated with paclitaxel resistance and immunosuppressive microenvironment in head and neck cancer
por: Chen, Kailin, et al.
Publicado: (2022)

G6PD promotes cell proliferation and dexamethasone resistance in multiple myeloma via increasing anti-oxidant production and activating Wnt/β-catenin pathway
por: Li, Rui, et al.
Publicado: (2022)

HNRNPA2B1 promotes multiple myeloma progression by increasing AKT3 expression via m6A-dependent stabilization of ILF3 mRNA
por: Jiang, Fengjie, et al.
Publicado: (2021)

Combination of targeting CD24 and inhibiting autophagy suppresses the proliferation and enhances the apoptosis of colorectal cancer cells
por: Zhuo, Jingwei, et al.
Publicado: (2019)

CHEK1 and circCHEK1_246aa evoke chromosomal instability and induce bone lesion formation in multiple myeloma
por: Gu, Chunyan, et al.
Publicado: (2021)

Elesclomol elevates cellular and mitochondrial iron levels by delivering copper to the iron import machinery
por: Garza, Natalie M., et al.
Publicado: (2022)

Elevated autophagy and mitochondrial dysfunction in the Smith–Lemli–Opitz Syndrome
por: Chang, Shaohua, et al.
Publicado: (2014)

Suppression of steroid 5α-reductase type I promotes cellular apoptosis and autophagy via PI3K/Akt/mTOR pathway in multiple myeloma
por: Dou, Renjie, et al.
Publicado: (2021)

Autophagy limits proliferation and glycolytic metabolism in acute myeloid leukemia
por: Watson, AS, et al.
Publicado: (2015)

Regulatory role of DEPTOR-mediated cellular autophagy and mitochondrial reactive oxygen species in angiogenesis in multiple myeloma
por: Wang, Jizhen, et al.
Publicado: (2021)

Dihydroartemisinin Induces Growth Arrest and Overcomes Dexamethasone Resistance in Multiple Myeloma
por: Chen, Ying, et al.
Publicado: (2020)

Corrigendum: Dihydroartemisinin Induces Growth Arrest and Overcomes Dexamethasone Resistance in Multiple Myeloma
por: Chen, Ying, et al.
Publicado: (2021)

Autophagy supports mitochondrial metabolism through the regulation of iron homeostasis in pancreatic cancer
por: Mukhopadhyay, Subhadip, et al.
Publicado: (2023)

Google Earth elevation data extraction and accuracy assessment for transportation applications
por: Wang, Yinsong, et al.
Publicado: (2017)

Effect of the Interaction between Elevated Carbon Dioxide and Iron Limitation on Proteomic Profiling of Soybean
por: Soares, José C., et al.
Publicado: (2022)

Florfenicol-induced Mitochondrial Dysfunction Suppresses Cell Proliferation and Autophagy in Fibroblasts
por: Hu, Dongfang, et al.
Publicado: (2017)

Zonated induction of autophagy and mitochondrial spheroids limits acetaminophen-induced necrosis in the liver()
por: Ni, Hong-Min, et al.
Publicado: (2013)

Targeting MK2 Is a Novel Approach to Interfere in Multiple Myeloma
por: Guo, Mengjie, et al.
Publicado: (2019)

Microbial antigens-loaded myeloma cells enhance Th2 cell proliferation and myeloma clonogenicity via Th2–myeloma cell interaction
por: Tian, Faqing, et al.
Publicado: (2019)

Effect of bortezomib on proliferation and apoptosis of myeloma cells by activating Wnt/β-catenin signaling pathway
por: Dai, Yanling, et al.
Publicado: (2020)

Effect of Iron Limitation, Elevated Temperature, and Florfenicol on the Proteome and Vesiculation of the Fish Pathogen Aeromonas salmonicida
por: Kroniger, Tobias, et al.
Publicado: (2022)

NAT10 promotes cell proliferation by acetylating CEP170 mRNA to enhance translation efficiency in multiple myeloma
por: Wei, Rongfang, et al.
Publicado: (2022)

Non-enzymatic heparanase enhances gastric tumor proliferation via TFEB-dependent autophagy
por: Yang, Min, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_dngc529vjskbtkffotk2utvg9i